The National Institutes of Health is beginning a handful of studies to test possible treatments for long Covid, an anxiously awaited step in U.S. efforts against the mysterious condition that afflicts millions.
A more controversial study of exercise intolerance and fatigue also is planned, with NIH seeking input from some patient groups worried that exercise may do more harm than good for certain long COVID sufferers.
The National Institutes of Health is beginning a handful of studies to test possible treatments for long Covid, an anxiously awaited step in U.S. efforts against the mysterious condition that afflicts millions.
Monday's announcement from the NIH's USD 1.15 billion RECOVER project comes amid frustration from patients who've struggled for months or even years with sometimes-disabling health problems 바카라 with no proven treatments and only a smattering of rigorous studies to test potential ones.
바카라This is a year or two late and smaller in scope than one would hope but nevertheless it's a step in the right direction,바카라 said Dr. Ziyad Al-Aly of Washington University in St. Louis, who isn't involved with NIH's project but whose own research highlighted long Covid's toll. Getting answers is critical, he added, because 바카라there's a lot of people out there exploiting patients' vulnerability바카라 with unproven therapies.
Scientists don't yet know what causes long Covid, the catchall term for about 200 widely varying symptoms. Between 10 per cent and 30 per cent of people are estimated to have experienced some form of long Covid after recovering from a coronavirus infection, a risk that has dropped somewhat since early in the pandemic.
바카라If I get 10 people, I get 10 answers of what long Covid really is," U.S. Health and Human Services Secretary Xavier Becerra said. That's why so far the RECOVER initiative has tracked 24,000 patients in observational studies to help define the most common and burdensome symptoms 바카라 findings that now are shaping multipronged treatment trials. The first two will look at:
Whether taking up to 25 days of Pfizer's antiviral drug Paxlovid could ease long Covid, because of a theory that some live coronavirus, or its remnants, may hide in the body and trigger the disorder. Normally Paxlovid is used when people first get Covid-19 and for just five days.
Treatments for 바카라brain fog바카라 and other cognitive problems. They include Posit Science Corp.'s BrainHQ cognitive training program, another called PASC-Cognitive Recovery by New York City's Mount Sinai Health System, and a Soterix Medical device that electrically stimulates brain circuits.
Two additional studies will open in the coming months. One will test treatments for sleep problems. The other will target problems with the autonomic nervous system 바카라 which controls unconscious functions like breathing and heartbeat 바카라 including the disorder called POTS.
A more controversial study of exercise intolerance and fatigue also is planned, with NIH seeking input from some patient groups worried that exercise may do more harm than good for certain long Covid sufferers.
The trials are enrolling 300 to 900 adult participants for now but have the potential to grow. Unlike typical experiments that test one treatment at a time, these more flexible 바카라platform studies바카라 will let NIH add additional potential therapies on a rolling basis.
바카라We can rapidly pivot,바카라 Dr. Amy Patterson with the NIH explained. A failing treatment can be dropped without ending the entire trial and 바카라if something promising comes on the horizon, we can plug it in.바카라
The flexibility could be key, according to Dr. Anthony Komaroff, a Harvard researcher who isn't involved with the NIH program but has long studied a similarly mysterious disorder known as chronic fatigue syndrome or ME/CFS. For example, he said, the Paxlovid study 바카라makes all sorts of sense,바카라 but if a 25-day dose shows only hints of working, researchers could extend the test to a longer course instead of starting from scratch.
Komaroff also said that he understands people's frustration over the wait for these treatment trials, but believes NIH appropriately waited 바카라until some clues came in about the underlying biology," adding: 바카라You've got to have targets.바카라