Not Just Muzaffarpur, AES Is Spreading Across India And Doctors Are Baffled

There are two children and two sets of parents on every bed. Young mothers cradle limp children. Fathers fuss over immobile babies, barely visible through a maze of tubes and masks. Many more lie on the floor, with parents frantically fanning them to beat the stifling heat. Nurses and doctors run around. Machines blink and glow. High-pitched wailings hush the crowd, sometimes, as little bodies swathed in white are carried out. Or 바카라�Wapas jao (go back)바카라� protests ring out as TV anchors or ministers float in and out. But only for a moment. There바카라�s no time to grieve or get angry. The clock is ticking on very sick children.

Time is running out. The shocked nation watches, as heart-wrenching images and stories of suffering from ground zero바카라�Muzaffarpur district in North Bihar바카라�flash across newspapers and television screens. Children are dying like flies every day. A mystery killer is claiming little lives in the blink of an eye: 9 children by June 2, 50 by June 13, 136 by June 20, 170 by June 25. Some 700 children have already been infected across 16 districts in less than a month. Stark statistics are on the wall: it has killed over 60,000 across India in 2010-16, nearly 50 per cent of those who were infected. There바카라�s fear in the air. Hundreds are fleeing villages. The chamki bukhar is running faster and it is winning the race, they say.

Fear without a name

It바카라�s a fear that has no name and no definition: Acute Encephalitis Syndrome (AES) is a basket coinage by the World Health Organisation (WHO) in 2008 for lethal brain fever that hits children hard but remains elusive to doctors and scientists. That바카라�s because, more than 100 different types of viruses, bacteria, parasites and fungi can cause AES symptoms, 50 per cent of the cases are caused by 바카라�unknown바카라� agents and 90 per cent have no specific treatment. Hence, patients stay undiagnosed and untreated as the mystery killer sweeps through its territory, counting its victims. If it is not contained soon, India will face an unprecedented situation for which it does not have a plan. 바카라�Basket terms are never good in science and AES has turned into a public health conundrum,바카라� says epidemiologist Jayaprakash Muliyil of Christian Medical College, Vellore, a man who has led India바카라�s battle against infections for long. 바카라�What is sad is that we have the knowledge base and the technology, yet we have not been able to sort it out. This magnitude of loss is unpardonable. We have lost our priority.바카라�

The outbreak began in the small villages that line the ancient Sarayu river, just as the tall groves of litchi trees lit up with fiery red fruits. Every summer children run around the orchards, play all day long, pick up fruits from the ground, and eat as many as they can. And every summer since 1995, the outbreak flares. Children die painful, unexplained deaths, racked with convulsive seizures, stiff limbed and disoriented바카라�signs of brain inflammation (see graphic). What do they die of? Scien­tists have not been able to figure out the root cause yet.

The world of science is scanning for evidence. Hypothesis and theories are being reviewed. All stripes of investigating teams have come on board, to carry out field surveys, collect biological samples, probe virological markers. And they are all advocating theories according to their areas of interests. Thickets of medical jargon and numbers are making the shroud of confusion thicker. The litchi is under the scanner. Muzaffarpur, India바카라�s 바카라�land of litchi바카라�, supplies the bulk of the country바카라�s harvest and the classiest varieties. To some, it is the toxin, amino acid hypoglycin A, naturally found in litchis, that causes fatal brain inflammation in undernourished children. Don바카라�t lab tests reveal very low blood glucose levels caused by high concentrations of the same amino acids in their body? Litchi scare has hit sales, affecting the very children whose families depend on the fruit for livelihood.

Others point to six-month-old victims. Surely, they couldn바카라�t have eaten litchi? Nothing explains why only some children in a village, or only one in a family, are affected and not the others. Or why, even in July in earlier years, when all the lit­chis have been harvested, AES cases still continue in Muzaffarpur? With Bihar spending a mere Rs 348 per person per year on healthcare바카라�less than half the national average of Rs 724바카라�primary and community health centres often do not work and treatment facilities are not available at places where cases occur the most. About 91 per cent deaths are believed to happen because the patient travels for over an hour to reach a hospital, say yet others. Some point to pollution, ground water contamination and heat stroke, all adding to the burden of severe malnutrition, immune deficiency and depressed metabolic rates. Increasingly, a viral explanation for the fatal illness in children is gaining ground.

India under siege

Even as Bihar struggles to contain the outbreak, 16 children have died of AES in neighbouring Uttar Pradesh. Rajasthan has directed health officials to stay on alert against sporadic cases it has witnessed since 2016. Doctors at Kolkata and Kozhikode are warning of rising encephalitis cases from an atypical source, while Mizoram has been in the grip of an outbreak since January. Karnataka바카라�s Shimoga district is still reeling from the deadly encephalitis triggered by a little-known virus. According to the National Vector Borne Diseases Control Programme (NVBDCP), AES cases have occurred typically in the rice-belts of Assam, Uttar Pradesh, West Bengal, Odisha, Tamil Nadu, Karnataka, Manipur, and Tripura so long. But in 2018, about 10,485 cases have taken place across 17 states, shows NVBDCP data. AES is clearly spreading its tentacles across India.

As scientists find ways to combat a pathogen in the AES basket, new ones come up to claim more lives.  The first case of AES was reported in India in 1955 from Vellore, Tamil Nadu, and the first major outbreak in 1973 from Bardhaman district of West Bengal. Since then, AES and Japanese Encephalitis Virus (JEV) have been reported from 171 districts of 19 states. But after the introduction of a JEV vaccine in 2005 and launch of surveillance guidelines by the NVBDCP, cases have come down. 바카라�Once the incidence of JE falls, AES caused by other neuropathogenic agents are unmasked,바카라� says Dr Rajnish Joshi of AIIMS Bhopal.

That바카라�s what has happened. Coming to the fore since the 2000s is a host of microbes: Herpes Simplex virus, Enterovirus, Nipah virus, Chandipura virus, Scrub Typhus bacteria, West Nile Virus, the Kyasanur Forest Virus. Most of these have not been seen as outbreaks affecting a large population in this country. The mechanisms that regulate them or the vectors they use for transmission are not understood enough. Most are not taught in medical schools. There are no clinical guidelines for doctors on these. What바카라�s more, there is very little immunity against them in general population. Hence, they pose a much more deadly threat in the future. 바카라�Many of these outbreaks occur in hot and humid seasons, predominantly affect children, and have a high case-fatality,바카라� adds Joshi. But in absence of a definite viral diagnosis for each, it is very difficult to treat patients, he explains. This conquest of new territories by AES and its newer forms imply that new risks have now to be taken into account. And India will now have to live with that threat.

Viruses, parasites and bacteria that prey on humans are microscopic predators, called pathogens. They cause infectious diseases and spread from one person to another through food, touch, air and water. Some spread from the environment, through animals. Within AES, different pathogens follow different routes, but all affect the human central nervous system (CNS), can cause serious complications and death바카라�children being at highest risk because of their immature immunity. Those who survive often end up with neurological, physical and psychological consequences.

Viruses are believed to form a significant proportion of AES in children. Their actual contribution, however, is not entirely known, because other causes바카라�from benign tumours, cerebral malaria, several disorders of the central nervous system to the 바카라�unknown바카라� causes바카라�mimic AES. Studies have reported central nervous system involvement among a substantial number of scrub typhus bacteria in patients from Dehradun, Vellore, Puducherry and Lucknow, explains Dr Manoj V. Murhekar, director of the National Institute of Epidemiology, Chennai. The bacterial malady transmitted by a microscopic mite has been found to be an important cause of AES in Bihar last year, for the first time. 바카라�Policy makers should consider investigations for scrub typhus as part of the surveillance algorithm for AES cases,바카라� Murhekar adds.

Viral pathogens behind AES, however, are much more let­hal compared to the non-viral. What is known about them? JEV is an arbovirus, transmitted to humans by insects바카라�typically, the culex mosquito. The Chandipura Virus (CHPV) is a rhabdovirus, a poorly characterised new virus that is, that mutates incessantly바카라�making it particularly lethal. CHPV is transmitted by sand flies and culex mosquitoes. Bats are reservoir of many highly infectious AES pathogens: Nipah virus and West Nile virus to Kyasanur forest disease virus. Herpes Simplex Virus, the most common cause of AES among children in Eastern India, spreads person-to-person. Enteroviruses, increasingly recognised as an important pathogen for AES, spread via water, food and soil. Rotavirus, the prime culprit behind the daily deaths from diarrhoea among children, can also cause hypoglycaemia (extremely low sugar in blood) and convulsions. And, despite the 1.2 lakh diarrhoeal deaths among children every year, Bihar is still to introduce the free rotavirus vaccine.

Tinkering with nature

The biggest challenge lies elsewhere. As the viral theory gains ground, AES becomes a spectrum of zoonotic diseases, where the pathogen jumps species and is transferred from animals to humans. In the 21st century, zoonotic diseases have caught the world unprepared: from the Severe Acute Respiratory Syndrome (SARS) to the Avian Influenza, the Acute Respiratory Syndrome from Nipah virus, Swine Flue, MERS, Kendra to Ebola and Zika바카라�every global epidemic has been a zoo­notic disease. Armed with a host of emerging viruses, they are rising: over one billion and more cases of zoonotic disease are estimated to occur among humans every year, reports the WHO. About 60 per cent of the roughly 400 emerging infectious diseases since 1940 have been zoonotic.

The warning signs have been there. Forest cover in Bihar came down sharply after bifurcation with Jharkhand in 2000, and stood at a poor 7.23 per cent. Even now, the state is a long way off from the desired mandate of 33 per cent. Muzaffarpur was known for its forests and wildlife once. The district is completely devoid of any forest now. 바카라�With continuous extension of the area under cultivation, wild buffaloes, gazelle, deer and tiger have disappeared,바카라� reports a 2016 central government report. The only wild animals sometimes seen are the fox and the jackal, besides nilgais and wild boars. Rampant construction of roads and dams, commercial plantations, indiscriminate and illegal sand mining by the 바카라�balu mafia바카라� has narrowed down the width of most rivers: the Sarayu is a haunt of smugglers.

Tinkering with nature has made the Muzaffarpur area particularly vulnerable to infectious zoonotic diseases. These diseases appear in areas that have gone through large-scale change in land use and human activity, leading to ecological degradation. Infections spread fast here, because wild life바카라�carriers of some of the viruses바카라�move closer to humans. In case of AES, fruit bats have migrated in thousands to the edges of villages, cities and towns in search of food, and started living in litchi orchards, in close proximity to humans바카라�as with the Ebola and the Nipah outbreaks. 바카라�The virus spread from animal faeces, fluids, infected fruits, meat, milk or water,바카라� says Nina Sengupta, ecologist and biodiversity conservation consultant, Pondicherry. 바카라�Children gorging on litchis can easily pick up fruits contaminated by the saliva, urine, or guano of bats.바카라� Bats host more than 60 human-inf­ecting viruses바카라�including the Ebola and Nipah viruses, which cause deadly brain fevers in people. Wading birds are the natural maintenance hosts of many of the AES viruses, pigs are known to be the main amplifying hosts, while mosquitoes and sandflies, that thrive near litchi trees and feed on bats, are the primary vectors, she explains.

Others point to ground water contamination with faeces in open-defecation villages. 바카라�Several enteroviruses, primarily spread by faecal-hand-oral contamination, are known to cause fatal encephalitis in children,바카라� says Dr Pratip Kundu, director of the Calcutta School of Tropical Medicine. In Bihar, the groundwater in many of the villages has been found to be 35.7 times more at risk of faecal contamination, according to a UNICEF 2019 study. Shallow wells and hand pumps contaminate drinking water with faecal matter are also a major problem in Bihar. A recent study by Girish Kumar Singh, director of AIIMS, Patna, uses virus-tracking software to show how open defecation flows into the Sarayu river in Muzaffarpur, Bihar, down the Gandak river in Gorakhpur, Uttar Pradesh, causing AES in that area. Muzaffarpur is also well-known for using human faeces as fertilisers in litchi orchards. Scientists are now linking the AES deaths to unhygienic conditions of households and rod­ent infestation. Rats carry parasites, like, rat flea, chigger mites, ticks and lice바카라�all established scrub typhus vectors.

Panic button

AES and the dying children of Bihar have evoked sharp reaction from all quarters. There is finger-pointing at India바카라�s creaking healthcare바카라�the stench of urine, chlorine, vomit, the dearth of health workers and absence of basic provisions at district hospitals. Senior doctors are being suspended for 바카라�negligence바카라�. Protest marches are being organised against government 바카라�apathy바카라�. Muzaffarpur-based Dr Arun Shah of the Indian Association of Paediatrics has touched a raw nerve by pointing a finger at chief minister Nitish Kumar for not implementing guidelines drafted in 2015 to prevent future attacks: 바카라�Anganwadi and ASHA workers were supposed to spread awareness. Instead they were busy with election duties.바카라�

Bihar minister of health Mangal Pandey, who initially refuted reports of children dying of AES in Muzaffarpur, has had to backtrack in face of intense criticism, visit the hospital and announce six ambulances for the institute and enhancing its ward capacity to 100. Union health and family welfare minister Harsh Vardhan has been criticised for reiterating his 2014  proposal of building a virology laboratory in Muzaffarpur, still a promise. Protests greeted Nitish Kumar when he visited AES patients to review the situation. What바카라�s more, the epidemic has sparked a debate over Prime Minister Narendra Modi바카라�s free healthcare scheme for the poor, Ayushmann Bharat, launched in 2018.

A public interest litigation has been filed at the Supreme Court by an advocate, Manohar Pratap. It claims that the measures taken by the Bihar government are inappropriate and inadequate to control the outbreak in Muzaffarpur. It is also seeking appropriate directions from the court to the state as well as to the Centre for ensuring necessary medical equipment and support for the effective treatment of children suffering from encephalitis. In response to an FIR lodged by social activist Tamanna Hashmi, the chief judicial mag­istrate of Muzaffarpur has ordered an investigation against Vardhan and Pan­dey, on grounds of negligence.

In the heat of the moment it has gone out of collective memory that India has successfully coped with the highly contagious avian flu and swine flu outbreaks. AES is, unfortunately, dangerous, expensive and time-consuming. The spectrum of pathogens and the diseases they can unleash needs better surveillance and research, hospitals need not just add beds but also expensive machinery, apart from more staff to treat the sick, more efforts are needed to understand patient history and symptoms. That involves complex assays, blood tests and culture, oxygen and intravenous drips, lumber puncture, neuroimaging facilities like EEG, MRI and CT scan, which do not come cheap.

Does India have a choice? There바카라�s a devastation waiting to happen anywhere and everywhere. And the bad news is: time is seriously running out. The cost of not combating AES on war-footing will be far greater than any cost of preparation. As Muliyil says, 바카라�It바카라�s like the Mumbai floods. We have both the knowledge and the know-how to avoid the dangers, but we won바카라�t do it. Somewhere, I hope better sense prevails. And the system finds a solution바카라�.

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AES In India

1,25,030 cases between 1978 and 2011. Cause of 68-75% unknown

2014

• Cases: 10,867

• Deaths: 1,719

2015

• Cases: 9,854

• Deaths: 1,210

2016

• Cases: 11,651

• Deaths: 1,301

2017

• Cases: 3,558

• Deaths: 279

2018

• Cases: 11,388

• Deaths: 636

Source: The National Vector Borne Diseases Control Programme (NVBDCP)